Séminaire de l'INPHYNI: Lou Boulant --

  • Science et Société
Publié le 2 octobre 2026 – Mis à jour le 9 novembre 2026
Date(s)

le 15 décembre 2026

Café : 15h
Séminaire: 15h15
Lieu(x)
Salle des séminaires

Fibrin matrices dissolution enhanced by self-assembling microswimmers: toward an improved ischemic strokes treatment (Lou Boulant) --

Seminars of the Institut de Physique de Nice, PhD Series

Abstract:

Lou Boulant - Fibrin matrices dissolution enhanced by self-assembling microswimmers: toward an improved ischemic strokes treatment

Ischemic stroke results from the obstruction of cerebral blood vessels by a clot, requiring rapid restoration of blood flow to limit severe aftereffects. However, thrombolysis is limited by the slow diffusion of thrombolytic drugs toward the clot. Here, we investigate self-assembled magnetic microswimmers to enhance drug transport. Under a weak rotating magnetic field, iron oxide nanoparticles assemble into micrometric aggregates whose collective motion generates a recirculating flow, convectively transporting the drug toward fibrin clots. In vitro microfluidic experiments demonstrate a nearly tenfold increase in fibrin-clot dissolution rate compared with passive diffusion, highlighting a promising strategy for accelerating thrombolytic treatment.

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