Séminaire de l'INPHYNI: Lou Boulant -- Shiyi Wei

Lou Boulant - Fibrin matrices dissolution enhanced by self-assembling microswimmers: toward an improved ischemic strokes treatment

Ischemic stroke results from the obstruction of cerebral blood vessels by a clot, requiring rapid restoration of blood flow to limit severe aftereffects. However, thrombolysis is limited by the slow diffusion of thrombolytic drugs toward the clot. Here, we investigate self-assembled magnetic microswimmers to enhance drug transport. Under a weak rotating magnetic field, iron oxide nanoparticles assemble into micrometric aggregates whose collective motion generates a recirculating flow, convectively transporting the drug toward fibrin clots. In vitro microfluidic experiments demonstrate a nearly tenfold increase in fibrin-clot dissolution rate compared with passive diffusion, highlighting a promising strategy for accelerating thrombolytic treatment.

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Shiyi Wei - Fluctuations in noisy quantum diffusive systems out-of-equilibrum

Equilibrium statistical mechanics provides a general framework for characterizing many-body systems, while no comparably universal framework is known out of equilibrium. In this talk, I will present boundary-driven noisy quantum systems with diffusive transport. More specifically, I will consider the Quantum Symmetric Simple Exclusion and Inclusion Processes (QSSEP and QSSIP), solvable models describing fermionic and bosonic particles undergoing stochastic quantum hopping. I will focus on density and current fluctuations and their large-deviation statistics. A central theme is that these fluctuations exhibit classical behavior at leading macroscopic order, while genuinely quantum corrections survive beyond it. I will conclude by discussing possible connections to universal fluctuation phenomena in quantum transport.